More and more people are weighing in with their experiences using the G1 garbage collector and Cassandra. Rumor has it that it enables the use of enormous heap sizes, with little to no tuning required, while still out-performing CMS. If true, it could have significant impact on our node-density story, and seems worth looking into.
G1GC will be the default in Cassandra 3.0.
See also: https://issues.apache.org/jira/browse/CASSANDRA-7486