Avoid its usage on production, at least the version that has crashed to me (bundled on MariaDB 10.0.16).
Evaluate if the bugs of TokuDB tables crashing:
Error 'Incorrect key file for table 'user_newtalk'; try to repair it' on query. Default database: 'dewiki'. Query: ...
and replication failing are version-specific or the engine is in general not prepared for large usage.
Good thing is that when the table fails, it complains and the errors do not seem fatal.
If the second, evaluate other options (InnoDB compressed, column-based engines, etc.).
For now, ALTER TABLE table_name ENGINE=TokuDB; is a workaround that fixes the issue.