The new masters in eqiad might not have all the configurations of the old ones.
Double check and ensure that they are properly configured.
First things to check that come to my mind or I've seen different between db1041 and db1033 investigating on T133309:
- semi-sync replication: rpl_semi_sync_%
- sync_binlog (and similar)
- binlog expiration: expire_logs_days
- connect_timeout
- wait_timeout
- userstat
Evaluate the need of having local_infile enabled on misc/core services (T214248)