This happens for about 1600 requests per day, or 0.02% of all requests.
This scenario results in Nginx serving a 502. The nginx error log shows things like the following where several pending requests on the same Thumbor instance die at the same time:
2017/03/28 15:05:15 [error] 2318#2318: *30599 upstream prematurely closed connection while reading response header from upstream, client: 10.64.0.38, server: , request: "GET /wikipedia/commons/thumb/e/ee/The_Holy_Bible_faithfvlly_translated_into_English_ovt_of_the_authentical_Latin%2C_diligently_conferred_with_the_Hebrew%2C_Greek%2C_%26_other_Editions_in_diuers_languages.pdf/page482-659px-thumbnail.pdf.jpg HTTP/1.1", upstream: "http://127.0.0.1:8806/wikipedia/commons/thumb/e/ee/The_Holy_Bible_faithfvlly_translated_into_English_ovt_of_the_authentical_Latin%2C_diligently_conferred_with_the_Hebrew%2C_Greek%2C_%26_other_Editions_in_diuers_languages.pdf/page482-659px-thumbnail.pdf.jpg", host: "thumbor.svc.eqiad.wmnet:8800" 2017/03/28 15:05:15 [error] 2340#2340: *30319 upstream prematurely closed connection while reading response header from upstream, client: 10.64.0.38, server: , request: "GET /wikipedia/commons/thumb/2/22/Las_Estrellas_%282016_Logo%29.png/375px-Las_Estrellas_%282016_Logo%29.png HTTP/1.1", upstream: "http://127.0.0.1:8806/wikipedia/commons/thumb/2/22/Las_Estrellas_%282016_Logo%29.png/375px-Las_Estrellas_%282016_Logo%29.png", host: "thumbor.svc.eqiad.wmnet:8800" 2017/03/28 15:05:15 [error] 2338#2338: *36089 recv() failed (104: Connection reset by peer) while reading response header from upstream, client: 10.64.32.221, server: , request: "GET /wikipedia/commons/thumb/7/76/Logo_Tournament_of_Champions_2012.jpg/130px-Logo_Tournament_of_Champions_2012.jpg HTTP/1.1", upstream: "http://127.0.0.1:8806/wikipedia/commons/thumb/7/76/Logo_Tournament_of_Champions_2012.jpg/130px-Logo_Tournament_of_Champions_2012.jpg", host: "thumbor.svc.eqiad.wmnet:8800" 2017/03/28 15:05:15 [error] 2339#2339: *36127 recv() failed (104: Connection reset by peer) while reading response header from upstream, client: 10.64.32.220, server: , request: "GET /wikipedia/commons/thumb/c/c7/Modigiliani_13.jpg/344px-Modigiliani_13.jpg HTTP/1.1", upstream: "http://127.0.0.1:8806/wikipedia/commons/thumb/c/c7/Modigiliani_13.jpg/344px-Modigiliani_13.jpg", host: "thumbor.svc.eqiad.wmnet:8800" 2017/03/28 15:05:15 [error] 2337#2337: *36167 recv() failed (104: Connection reset by peer) while reading response header from upstream, client: 10.64.0.39, server: , request: "GET /wikipedia/commons/thumb/7/7f/Absence_makes_the_heart_grow_fonder_ HTTP/1.1", upstream: "http://127.0.0.1:8806/wikipedia/commons/thumb/7/7f/Absence_makes_the_heart_grow_fonder_", host: "thumbor.svc.eqiad.wmnet:8800" 2017/03/28 15:05:15 [error] 2331#2331: *36199 recv() failed (104: Connection reset by peer) while reading response header from upstream, client: 10.64.0.38, server: , request: "GET /wikipedia/en/thumb/5/5a/Seymourstill.JPG/200px-Seymourstill.JPG HTTP/1.1", upstream: "http://127.0.0.1:8806/wikipedia/en/thumb/5/5a/Seymourstill.JPG/200px-Seymourstill.JPG", host: "thumbor.svc.eqiad.wmnet:8800" 2017/03/28 15:05:15 [error] 2336#2336: *36611 recv() failed (104: Connection reset by peer) while reading response header from upstream, client: 10.64.0.38, server: , request: "GET /wikipedia/en/thumb/a/af/Time_crystal_phase_transition.png/320px-Time_crystal_phase_transition.png HTTP/1.1", upstream: "http://127.0.0.1:8806/wikipedia/en/thumb/a/af/Time_crystal_phase_transition.png/320px-Time_crystal_phase_transition.png", host: "thumbor.svc.eqiad.wmnet:8800" 2017/03/28 15:05:15 [error] 2335#2335: *36709 recv() failed (104: Connection reset by peer) while reading response header from upstream, client: 10.64.0.39, server: , request: "GET /wikipedia/commons/thumb/e/e1/Portal_icon.svg/15px-Portal_icon.svg.png HTTP/1.1", upstream: "http://127.0.0.1:8806/wikipedia/commons/thumb/e/e1/Portal_icon.svg/15px-Portal_icon.svg.png", host: "thumbor.svc.eqiad.wmnet:8800" 2017/03/28 15:05:15 [error] 2326#2326: *37371 recv() failed (104: Connection reset by peer) while reading response header from upstream, client: 10.64.0.39, server: , request: "GET /wikipedia/en/thumb/0/0c/Red_pog.svg/6px-Red_pog.svg.png HTTP/1.1", upstream: "http://127.0.0.1:8806/wikipedia/en/thumb/0/0c/Red_pog.svg/6px-Red_pog.svg.png", host: "thumbor.svc.eqiad.wmnet:8800" 2017/03/28 15:05:15 [error] 2333#2333: *37255 recv() failed (104: Connection reset by peer) while reading response header from upstream, client: 10.64.32.220, server: , request: "GET /wikipedia/commons/thumb/3/33/Korean.food-Seolleungtang-01.jpg/260px-Korean.food-Seolleungtang-01.jpg HTTP/1.1", upstream: "http://127.0.0.1:8806/wikipedia/commons/thumb/3/33/Korean.food-Seolleungtang-01.jpg/260px-Korean.food-Seolleungtang-01.jpg", host: "thumbor.svc.eqiad.wmnet:8800" 2017/03/28 15:05:15 [error] 2334#2334: *37035 recv() failed (104: Connection reset by peer) while reading response header from upstream, client: 10.64.32.220, server: , request: "GET /wikipedia/commons/thumb/9/9b/Seneca-berlinantikensammlung-1.jpg/220px-Seneca-berlinantikensammlung-1.jpg HTTP/1.1", upstream: "http://127.0.0.1:8806/wikipedia/commons/thumb/9/9b/Seneca-berlinantikensammlung-1.jpg/220px-Seneca-berlinantikensammlung-1.jpg", host: "thumbor.svc.eqiad.wmnet:8800" 2017/03/28 15:05:15 [error] 2332#2332: *37751 recv() failed (104: Connection reset by peer) while reading response header from upstream, client: 10.64.32.220, server: , request: "GET /wikipedia/id/thumb/5/53/Pinkan_Mambo.png/720px-Pinkan_Mambo.png HTTP/1.1", upstream: "http://127.0.0.1:8806/wikipedia/id/thumb/5/53/Pinkan_Mambo.png/720px-Pinkan_Mambo.png", host: "thumbor.svc.eqiad.wmnet:8800" 2017/03/28 15:05:15 [error] 2330#2330: *37589 recv() failed (104: Connection reset by peer) while reading response header from upstream, client: 10.64.0.38, server: , request: "GET /wikipedia/commons/thumb/5/50/TehranIranSkyline.jpg/800px-TehranIranSkyline.jpg HTTP/1.1", upstream: "http://127.0.0.1:8806/wikipedia/commons/thumb/5/50/TehranIranSkyline.jpg/800px-TehranIranSkyline.jpg", host: "thumbor.svc.eqiad.wmnet:8800" 2017/03/28 15:05:15 [error] 2301#2301: *38695 recv() failed (104: Connection reset by peer) while reading response header from upstream, client: 10.64.32.221, server: , request: "GET /wikipedia/commons/thumb/3/3c/Pharoah%27s_Daughter_-Pas_de_Fleche_-Mathilde_Kschessinska_-1898_-2.JPG/383px-Pharoah%27s_Daughter_-Pas_de_Fleche_-Mathilde_Kschessinska_-1898_-2.JPG HTTP/1.1", upstream: "http://127.0.0.1:8806/wikipedia/commons/thumb/3/3c/Pharoah%27s_Daughter_-Pas_de_Fleche_-Mathilde_Kschessinska_-1898_-2.JPG/383px-Pharoah%27s_Daughter_-Pas_de_Fleche_-Mathilde_Kschessinska_-1898_-2.JPG", host: "thumbor.svc.eqiad.wmnet:8800"
What's unclear is why the proxy_next_upstream settings aren't kicking in and resulting in a retry on a different upstream.