We have 2 things that would be helpful to us to turn on that we just haven't done. Initially the reason was code freeze for Redis but that is over. The actual work involved in this change is around 10 minutes but logging a phab so we can track when we make the change & can keep an eye on queues / grafana for a bit immediately afterwards
They are
Redis - from our testing this gives around 10-15% UI page load performance improvement (no impact on queues)
Functional locks - this will reduce deadlocks a little - although probably more so if we start to make code changes to take advantage of it - the define is
define('CIVICRM_SUPPORT_MULTIPLE_LOCKS', TRUE);