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Sequelize seems to be a good ORM for nodejs + MySQL/MariaDB, which relies on the official mariadb driver node package.
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If we're going to go the ORM route, that looks like a good choice, at least insofar as it looks like the most popular choice out there. We could also consider a query builder (e.g., knex) to get a nicer interface in JS without the potential inefficiencies of a full-on ORM.