I have seen the following error in the journal:
May 18 07:31:24 cp2040 systemd[1]: /lib/systemd/system/nagios-nrpe-server.service:12: PIDFile= references path below legacy directory /var/run/, updating /var/run/nagios/nrpe.pid → /run/nagios/nrpe.pid; please update the unit file accordingly.
The warning seems easy to fix by updating the PIDFile directive in modules/nrpe/templates/initscripts/nagios-nrpe-server.systemd.erb.