We can assume that a user who disabled the Homepage is not interested by being mentored. As a consequence, we should remove this user from the view of its mentor, and remove them from the mentor/mentee relationship database. This would avoid the ex-mentee to be still visible on the mentor dashboard or in the filters their former mentor uses.
Disabling the homepage should inform the user about the loss of all benefits it provides.
Could be combined with T287915: Mentorship: allow newcomers to opt-in and opt-out of mentorship.