Latest Chrome/Chromium releases (and most likely current browsers built upon Blink) display a deprecation warning when accessing a U2F hardware key:
This site won't be able to use the U2F API after February 2022. If you own this site, you should change it to use the Web Authentication API.
Announcement by Google on this: https://groups.google.com/a/chromium.org/g/blink-dev/c/xHC3AtU_65A?pli=1
Current CAS releases already support the web auth API, but we need to test/deploy it out.