On visits to Special:Homepage, CacheDecorator is supposed to fetch a cached taskset list (a JSON representation of the TaskSet class). If the cache is expired or the filters don't match what is stored in the cache, then a new cache item should be generated by calling ElasticSearch (which is slow).
Update: @Urbanecm_WMF noticed this has to do with AND topic filtering enabled.
This seems to work on all the wikis I've looked at except for cswiki, where I see "CacheDecorator miss" (logs) on each page view when using the WikimediaDebug extension with verbose logging. I can also verify that by looking at the XHGui report for Special:Homepage on cswiki (XHGui report) where we can see that CacheDecorator::suggest is consistently in the several hundred ms range; compare to enwiki where fetching from cache takes about 10ms.
I haven't been able to reproduce the issue on eswiki, arwiki, enwiki, or frwiki.