After a reboot of clouddb1001 earlier this week, the value for innodb_large_prefix changed to "false", and innodb_file_format changed to "Antelope", because those variables (introduced in [1]) were removed recently from the tools.my.cnf.erb file in [2] and [3], as they are set by default in MariaDB >=10.2.2, but we are still running 10.1.39 on clouddb1001.
I re-instated the values innodb_file_format=Barracuda and innodb_large_prefix=1 by manually running SET GLOBAL on clouddb1001:
SET GLOBAL innodb_large_prefix=1; SET GLOBAL innodb_file_format = 'Barracuda';
I think it's worth re-adding those to tools.my.cnf.erb, with a comment specifying that those variables will no longer be needed after we upgrade ToolsDB to MariaDB 10.4 in T301949.
[1] https://gerrit.wikimedia.org/r/c/operations/puppet/+/389477/
[2] https://gerrit.wikimedia.org/r/c/operations/puppet/+/837490/
[3] https://gerrit.wikimedia.org/r/c/operations/puppet/+/769025/