I'm tagging this as a security issue, because this issue is right now preventing any blocks from being imposed on at least the English Wiktionary, if not other wikis. Any sort of troublemakers could abuse this. This is no longer the case and may become a public ticket soon.
The multiblock feature introduced in MW 1.44 brought with it a new "Manage blocks" page. This page seems to depend on an API query request in order to load correctly. An example XHR request sent by the UI for an IP looks like this:
https://en.wiktionary.org/w/api.php?action=query&format=json&list=blocks%7Cglobalallusers&bkusers=<IP>&bkprop=id%7Cuser%7Crange%7Ctimestamp%7Cexpiry%7Cby%7Creason%7Cflags&bkdir=older&agufrom=<IP>&aguto=<IP>&agulimit=1&aguprop=lockinfo
If this request fails to complete (e.g. because of a HTTP 502, like right now), the block interface never loads and it becomes impossible to block any users.
The block interface, at least for imposing blocks, is mission-critical, and should not be allowed to fail loading like this.
Note that the rest of the site seems to work fine (pages load and can be edited by users), so it's not a case where much of the site is down.