Some instances are suffering from CPU lockdown / slowness that make them rather unresponsive.
An example is deployment-parsoid05 which runs on virt1007 Ganglia view. The server has spikes of WIO but is otherwise low on CPU usage.
A dmesg T97421#1244842 shows a BUG: soft lockup - CPU#1 stuck for 23s! [nodejs:27358] error.
@Petrb reported a similar issue on huggle-d2 which runs on labvirt1005 (ganglia view).