It is currently possible to implement responsive skins using media queries in the RL modules and various bits of js to deal with the eccentricities of various mobile devices, but this requires extensive knowledge on the part of the skin developer to do.
This should not be necessary. It should be possible for the developers to simply tell the skin that styles and scripts are for a particular device type, and have the skinning system do the actual magic of making those styles and scripts show up for that instead of the other ones.
Currently this will likely require bad hacks to pull off, but waiting for a sane backend for the entire skinning system is not worth it; having this now will be well worth it for the many wikis out there that lack the resources to implement their own dedicated mobile app/rewrite MF for their needs.