Cassandra 4.1.5 —release date TBD— contains a fix that may resolve read timeouts during node decommissions, that seem to impact us (see: T360548: Cassandra quorum read timeouts during node decommissions).
Cassandra 4.1.4 —tentatively scheduled for next week— contains a fix for a streaming bug (CASSANDRA-18733) that seems to be effecting us (see: T352469: Decommission restbase20[13-20])).
See also:
• CASSANDRA-18733: Waiting indefinitely on ReceivedMessage response in StreamSession#receive() can cause deadlock
• CASSANDRA-19120: local consistencies may get timeout if blocking read repair is sending the read repair mutation to other DC