As of April, Commons allows uploading files up to 4GB: https://commons.wikimedia.org/wiki/Commons:Maximum_file_size
This TIFF, for instance, is 1,69GB: https://commons.wikimedia.org/wiki/File:Andromeda_Galaxy_M31_-_Heic1502a_Full_resolution.tiff
While other limits might prevent the thumbnail from rendering (memory, time), there's no reason no to try rendering a thumbnail for that image, considering that it's an acceptable upload on Commons and that huge TIFFs like that should be resized efficiently memory-wise thanks to VIPS.