Hi @ChristianKl, thanks for taking the time to report this!

The standard way to save a page in Wikipedia is Alt+Control+S.

Isn't that a function provided by your browser, and the exact shortcut depends on your browser and operating system?

It woud be great if the hotkey works to safe the Labels/description/alias list.

Where and how to see "the Labels/description/alias list"?

Unfortunately this report lacks some information. If you have time and can still reproduce the problem, please add a more complete description to this report. Ideally, exact and clear steps to reproduce should allow any other person to follow these steps (without having to interpret those steps) and see the same results. Problems that others can reliably reproduce can get fixed faster. Thanks!

I'm sorry I meant Alt+Shift+S.

A lot of Alt+Shift hotkeys aren't used by the browswer or the operation system.
Wikipedia assigns that hotkey traditionally to various functions.
There's
"Alt+Shift+S" to save a page that you edit.
"Alt+Shift+E" to edit the page.
"Alt+Shift+T" to go to the talk page.
"Alt+Shift+C" to go to the article page.
"Alt+Shift+V" to go to the visual editor.
(You can see these by hovering about the buttons in Wikipedia)

Wikidata directly copies some of those hotkeys. In many cases however Wikidata has functions that aren't mapped to hotkeys.
Given that "Alt+Shift+S" is in general supposed to save statements, I think that hotkey should work more widely within Wikidata. I think it would be easy to make it work in those two instances.