Whilst talking to @Danielgblack about T311106 he pointed out that if we have our fleet with SSDs we might want to re-check if we really need innodb_flush_neighbors=1, which we kept for when we didn't have all of them with SSDs.
More info also at: https://mariadb.com/kb/en/innodb-system-variables/#innodb_flush_neighbors and https://jira.mariadb.org/browse/MDEV-17380