People have used mutagen to successfully get close to native Linux performance on macOS. Of course, there are a lot of caveats, for example the Docker team decided not to include it in Docker for Mac (https://github.com/docker/roadmap/issues/7#issuecomment-705416084), but maybe it would work for our purposes.
In trying to set it up, I was blocked with our user/group setup with Apache/PHP-FPM. I couldn't specify a user to sync with because our image doesn't have one.