Every visitors gets an "mwuser-sessionId" cookie when the Popups extension is installed.
As far as I could see this is only used by statsv performance logging however even when
$wgPopupsStatsvSamplingRate
is set to 0 (the default), the cookie is still being created.
This behavior renders varnish caching useless as nothing gets cached due to the served cookies. I can configure varnish to ignore this specific cookie but then it would also ignore the valid cases when pages should not be cached when 'mwuser-sessionid' is served.